Wild Honey at TEDMED's the "Hive"

QMedic presenting real-time data at TEDMED's the Hive“Burn it down.”

Typically, you would expect such words from innovators targeting healthcare from the outside.  But what was so amazing about last week’s TEDMED Conference is that it was physicians—those in the trenches of healthcare—who must commonly uttered this phrase.   We must have heard this 30-40 times over the course of the week.

For the innovators in the Hive, this should be a call to arms, but the question remains of how to appropriately stage the escape fire: who leads (i.e. hubs), who follows (i.e. spokes), who sacrifices, and, of course, who pays.

At TEDMED, there were very few domesticated bees waiting for this fire to happen.  Most are carving out paths with an eye on clinical decision support tools, accessibility at the bottom of the pyramid, and subscription service API integration vs. standalone products.  Very few innovators are messing around with their own EHRs, for example, as this seems to be an area where a consolidated hub (e.g. Epic, AllScripts, etc.) is better for all stakeholders and more likely to make a dent in healthcare.

Here is a list of the 49 awesome Hive innovators that presented last week (in reverse alphabetical order):

Wello:  Wello helps to effectively deliver clean water to a thirsty world. Globally, over 1 billion people lack reliable access to safe water. The WaterWheel is a rolling water container that moves 50 liters of water in a single trip, 3-5 times more than the amount possible using traditional methods. Wello has developed an innovative business model to make the WaterWheel affordable – and help families become healthier. 

WellFrame:  Wellframe is focused on building the next generation of infrastructure for healthcare delivery using artificial intelligence. Our mission is to re-engineer the way care is delivered and extend the reach of healthcare outside the hospital. We are developing technology to optimize recovery among patients with complex high-cost diseases, including heart attacks/failure, organ transplant recovery, and cancer.

ViS: ViS is a new approach to finding researchers and sites for clinical trials. The platform puts comprehensive, up-to-date, analytics about research centers around the world at the fingertips of trial planners. ViS also provides a social network for sites to easily communicate their expertise. All of this information is efficiently shared through visualizations, computational engines, and communication tools, leading to faster and cheaper development of medical treatments.

VisualDx: Can your doctor know everything about you and all the medical literature to make an accurate diagnosis in 7 minutes? Doctors are only human. Logical Images improves diagnostic accuracy by combining a structured-knowledge approach, a visual search interface, more than 100,000 of the world’s best medical images, and deep medical expertise into VisualDx—helping doctors and empowering patients. VisualDx is used in almost half of all medical schools and more than 1500 hospitals nationwide.

VGBio: VGBio has developed a proprietary, personalized, predictive analytics based solution to wirelessly acquire and analyze multiple biological signals and reliably identify significant medical abnormalities earlier than current systems. Our solution provides daily monitoring of chronically ill patients, giving clinicians early notification of an exacerbation, enabling modified therapy to maintain the patient’s health and avoid costly hospitalizations. We seek to transform the management of chronic diseases from a reactive to a proactive care delivery model.

VentriNova:  VentriNova, Inc. develops treatments for cardiovascular disease based on the use of cyclin A2 to induce cardiac regeneration after myocardial infarction or in heart failure. VentriNova’s unique approach for heart regeneration relies on stimulating the endogenous fetal gene program that causes heart muscle cells to divide. The company was awarded a small-business grant from the NIH. Initial venture investment in VentriNova is through Broadview Ventures.

UpriseMedical: Uprise Medical is enabling a data-driven approach to patient education by creating a platform that centralizes educational content and allows clinicians to prescribe personalized playlists to patients. The design-driven solution combines patient education content from professional and clinician created sources, transforms it into an attractive patient facing learning experience, and tracks patient engagement with the content. Uprise’s analytics engine then flags patients that are unengaged and enables providers to manually or automatically follow-up. 

Starling: Starling creates technology to facilitate communication between patients and providers in hospitals and long-term care facilities. Its platform helps patients communicate specific needs directly from the bedside and provides a framework for care providers to resolve those requests. Patients receive a configurable set of icons that are supported by text and audio in any language to articulate needs. Staff can receive and resolve requests via dedicated touchscreen dashboards, web interfaces and mobile devices.

Spire: Spire’s Breathwear is the world's first truly clip-on-and-go respiration sensor. It streams a user's breathing patterns to a smartphone for real-time monitoring and guidance. Breathwear is virtually invisible yet tracks both physical behavior (i.e., steps) and mental/emotional behavior (anxiety, calm), making it a consumer-friendly means of providing real-time anticipation, prevention, and recovery from asthma attacks, hypertension, chronic pain, PTSD, and other stress- and cardiorespiratory-related disorders. Kickstarter campaign launching soon.

Soma Analytics:  SOMA Analytics is a London based startup that radically improves the way companies cope with the impact of work stress on their employees. Therefore SOMA Analytics quantifies and enhances employee well-being through real-time data analysis based on everyday smartphone interaction. Personalized feedback is provided for the individual and tailored organizational improvements are delivered for the company. With a patent pending technology and German software engineering SOMA Analytics brings back human in human resource management. 

ShapeUp:  ShapeUp is the leading global provider of clinically-proven, social networking-based employee wellness programs. Founded in 2006 by two doctors, ShapeUp pioneered an innovative behavior change approach that leverages the power of social networking, gaming, coaching, and financial rewards to improve the health of large populations and reduce healthcare costs. ShapeUp’s social wellness platform covers two million lives across 90 countries and is used by more than 200 employers and health plans.

Sensulin:  Sensulin, LLC is developing the first single dose 24-hour glucose-responsive insulin, which may mimic a healthy human pancreas. SensulinT may eliminate the need for basal and prandial insulin, offer a substantial improvement in the standard of care, and most importantly, give those with diabetes a chance at a normal life.

SenseHealth: SenseHealth helps healthcare providers deliver mobile support to patients in between appointments. Support is delivered to patients through text message plans called Scripts. Scripts interactively remind, motivate, and check-in with patients. We believe the key to helping patients improve their health lies in patient accountability, behavioral triggers, and individually tailored support. With SenseHealth, providers can now efficiently create, deliver, and monitor support plans for their patients in between appointments.

Science Exchange:  Science Exchange is a community marketplace for scientists to list, discover, access and pay for scientific services. The Exchange helps researchers access resources and expertise, and connect with providers who can conduct their experiments. Science Exchange was founded by Elizabeth Iorns, Ryan Abbott and Dan Knox in May 2011, and is based in Palo Alto, CA. The company is backed by Y Combinator, Andreessen Horowitz, Yuri Milner and Sam Altman, among others. 

RxAnte: RxAnte is an integrated analytics platform that predicts medication adherence for individual patients, provides intervention decision support, and measures intervention performance. RxAnte’s technology uses healthcare data to determine which patients need extra support and which medication improvement intervention is the best choice for each individual. The RxAnte system is currently in use by large healthcare payers, providers, and life sciences companies.

QMedic: QMedic enables seniors to age in place while keeping them connected, healthy, and safe in the home. QMedic’s wearable sensing platform passively monitors physical activity, sleep, and falls, and provides real-time alerts to caregivers to identify abnormal behaviors and emergency events. QMedic continuously samples behavioral data, does not require battery recharge, and uses machine learning to model and analyze long-term health decline.

PokitDok: PokitDok is a web and mobile health marketplace founded in 2011 and based in Menlo Park, California. PokitDok’s price transparent health marketplace contains a database of over 3 million healthcare providers nation wide. Consumers can shop directly from these providers for high value health services, search by condition or specialty and request a price quote directly from the provider before the service is performed.

Ovuline: Ovuline empowers women to understand and manage their health through technology. With our Smart Fertility and Smart Pregnancy products, Ovuline helps women conceive faster and have healthy pregnancies by analyzing users' key health metrics collected through self-reporting and quantified self devices. Ovuline then creates personalized recommendations for each user based upon her unique data set, clinical guidelines and insights gained from analysis from the 1M+ data points shared by our users. 

Open mHealth: While there might be an app for this and an "app for that", many mHealth applications are built in silos. Open mHealth aims to break down these silos by building an open architecture for mobile health applications.

Omada: Omada Health combines exceptional design with evidence-based medicine to create groundbreaking products that foster lifestyle change, prevent chronic disease, and reduce the burden of healthcare costs. Omada’s flagship product Prevent, based on the NIH-sponsored Diabetes Prevention Program clinical trial, is the first online diabetes prevention program for the general public. Prevent has demonstrated significant weight loss results for people with prediabetes by delivering a world-class, engaging 16-week program.

nVision: nVision is an early-stage, venture backed medical device company dedicated to filling the void in female health-related innovation. Our current areas of interest are reproductive health and early detection of ovarian cancer. Infertility is a five billion dollar (US alone and growing) market and we have developed a catheter-based device that will significantly advance the diagnosis of the leading cause of female infertility, fallopian tube blockage. Current iterations of this product will allow physicians to detect ovarian cancer in office at earlier, more treatable stages, therefore preventing the spread of this lethal cancer.

NudgeRx: NudgeRx provides an internet-based, post hospital daily discharge monitoring service that helps reduce unplanned readmissions and ER visits. The company's technology provides tools for patients and their caregivers to monitor, track and report a patient's status and adherence to their recovery plan. NudgeRx's proprietary backend software also allows call center nurses to assist and triage patients throughout recovery. The company's all-factors readmission rate for heart surgery patients is 12% for 30 days and 15% for 90 days with a 90% patient satisfaction rating.

Novocor Medical Systems: Novocor Medical Systems provides solutions that help Emergency Medical Service first responders save lives. Our patent pending product, HypoCore, is an innovative rapid chilling device for inducing therapeutic hypothermia in cardiac arrest, traumatic brain injury, heat stroke and heavily concussed patients to markedly improve patient survival rate. HypoCore is ready on demand. It is easily stored in ambulances, fire trucks, and helicopters. It does not require external power and is compatible with standard medical equipment.

New York eHealth Collaborative:  The goal of the New York eHealth Collaborative (NYeC) is to create health information technology that ensures fast, secure, accurate, and accessible patient data. NYeC helps providers shift to EHRs, develops policies and standards, and coordinates a state network of healthcare providers (SHIN-NY). NYeC deployed the first clinical API affording standardized access to the SHIN-NY with appropriate security and privacy policies. With the Partnership Fund for NYC, NYeC launched the New York Digital Health Accelerator, providing funding and access to providers for early-stage health tech companies.

Neurotrack:  Neurotrack's technology can diagnose Alzheimer’s Disease years before symptoms appear, enabling pharmaceutical companies and researchers to recruit qualified candidates for clinical trials and to more effectively measure drug efficacy, speeding up drug discovery and development. Neurotrack is on track to become the gold standard for early clinical screening of Alzheimer’s and dementia related disorders. 

Neumitra:  Neumitra is building wearable and mobile technologies for daily brain health. Our mission is to measure, monitor, and manage the daily effects of life demands on brain health, productivity, and happiness. Our first product is bandu, a self-learning biowatch that continuously measures the autonomic nervous system for personalized biofeedback, in the clinic and at-home. Dashboard analytics enable brain health and performance comparisons from one person to thousands across industries and the population. From veterans to mothers to executives and students, we bring data to mind to improve how we all live, work, and play.

Nanoly Bioscience: Nanoly Bioscience is developing a polymer that enables vaccines to survive without refrigeration. According to the World Health Organization (WHO), 2.1 million people die each year from vaccine-preventable diseases. People living in hard-to reach areas of the world struggle to receive immunization. Our technology decreases vaccine transportation costs, increases immunization access in remote areas of the world, and decreases vaccine spoilage.

Kinsa: Kinsa is advancing how people care for themselves and their families through unique mobile software and hardware products that help create a real-time map of human health. Our first product is an ultra-low-cost smartphone-connected thermometer. Caregivers can easily capture a temperature, seek advice from medical professionals, compare symptoms to "what's going around," and keep a health history. Together, all of our products give local parents and physicians the information needed to track and stop the spread of disease.  Support Kinsa on Indigogo.

Jintronix:  Jintronix is a biomedical device company designing software for physical rehabilitation. With offices in Montreal, Quebec, and Seattle, WA, it began as a passion project to help stroke victims recover. Now venture-capital funded, Jintronix has broadened its sights, developing tools to help both patients and physicians. By developing unique, engaging and effective software solutions, Jintronix’s goal is to provide everyone with an affordable means of receiving physical rehabilitation.

IntelligentM: IntelligentM designs data-driven hand hygiene compliance solutions to help reduce healthcare-acquired infections, which cause some 100,000 deaths annually but can be reduced by 70% if healthcare workers follow proper hand hygiene protocols. A novel technology allows "on the spot" notification to healthcare workers who are not washing or sanitizing their hands according to the CDC protocols, and provides comprehensive reporting of hand hygiene compliance at the individual level.

iMPak Health: iMPak Health develops low-cost, cloud connected devices and condition-specific solutions that capture and report "just enough" information to help medical providers and patients to collaborate and coordinate care and decrease costs for managing chronic conditions. The company’s initial efforts aim to enable patients to easily share clinically relevant data with physicians via low-cost sensor-based technologies, helping alert clinicians to events that may require interventions. iMPak is funded by Meridian Health.

Humetrix: Humetrix is the developer of the iBlueButton mobile Apps enabling over 70 million Americans to securely access their online Blue Button® and other health records, and to transmit these to their physicians– device to device- in a novel way. The iBlueButton apps won the 2012 HHS Industry Innovation "Blue Button Mashup" Challenge for putting in the hands of Medicare beneficairies actionable health records into their mobile devices, to save lives and $ billions of healthcare costs.

HealthifyHealthify is a Baltimore, M.D. based startup building a modular eHealth platform to help care teams address varied patient psychosocial risks and conduct smarter patient outreach. Our software improves health outcomes in primarily low-income populations by empowering patients with information on the basic resources needed to be healthy, contextualizing a patient’s environment for a healthcare provider, and leveraging mHealth tools to coordinate care and engage patients outside the clinical setting. We hope to effectively bring a patient’s social environment into the healthcare equation.

Health Tech Hatch:  Health Tech Hatch is a resource to organizations, health technology companies and individual entrepreneurs. Hatch cultivates early iterative feedback from selected end-users (consumers and providers) to make product development more effective and to prevent expensive rework, and hosts challenges to crowdsource solutions for government agencies, foundations, academic institutions and other organizations. An entrepreneur may also crowdfund for early seed funds on the Hatch platform.

Health Leads: Health Leads enables doctors and other healthcare providers to "prescribe" low-income patients basic resources like food and heat, just as they do medication and refer patients to Health Leads just as they do any other specialty. We train and mobilize college students who volunteer their time as advocates to "fill" prescriptions by working side by side with patients to connect them with the basic resources they need to be healthy.

Global Center for Medical Innovation: The Global Center for Medical Innovation (GCMI) is an independent, not-for-profit organization that launched the Southeast’s first comprehensive medical device innovation center. GCMI brings together core members of the medtech community, including universities, researchers, clinicians, industry, investors, and early-stage companies, with the goal of accelerating the commercialization of innovative medical technology. GCMI provides critical development infrastructure including equipment, cleanrooms, design & engineering expertise and partner network needed to help bring ideas from concept to market.

GeckoCap:  Gecko Health Innovations is founded by parents, engineers, and physicians from MIT and develops products that simplify medication adherence and improve the quality of life of those using chronic medications. GeckoCap motivates kids, engages parents, and informs clinicians. It includes a smart button that attaches to existing inhalers and an online user interface that provides direct monitoring, games, and data visualizations. GeckoCap also allows caregivers to monitor adherence on their mobile devices.

Galileo Analytics:  Galileo Analytics is a visual data exploration and advanced analytics company aimed at democratizing health data research. Galileo's visually dynamic, cloud-based platform, Galileo CosmosTM, helps researchers mine vast stores of complex data in real-time. Through a series of click, drag and drop menus, any user with a Web-enabled computer can rapidly generate and refine hypotheses, defining cohorts and validating assumptions. This enables researchers anywhere to view, analyze and share data, fueling scientific collaboration and catalyzing new understanding of health, disease and care.

Empower Interactive:  Empower Interactive, Inc. is a leading digital behavioral health company. Empower transforms the experience of evidence-based psychotherapy into interactive e-learning programs, teaching structured coping techniques to address behavioral health issues in a cost-effective, highly accessible way. Empower's programs, based on cognitive-behavior therapy, address these issues both in self-help settings and in conjunction with traditional talk therapy, where published clinical evidence shows they can reduce required clinician time by 50%.

Docphin:  Docphin helps healthcare providers save time and take better care of patients. Docphin’s research platform is a fast and elegant tool providing seamless access to national guidelines and the latest research. Docphin’s enterprise solution enables hospitals to better communicate institutional protocols to the right person at the right time. Docphin facilitates secure collaboration through this evidence-based content and enables hospitals to track and measure provider performance and compliance to meet new accreditation standards and improve quality of care.

Download My Data (Veterans’ Affairs/Blue Button):  The Department of Veterans Affairs (VA) operates the nation’s largest integrated healthcare system and administers a variety of benefits and services including financial, healthcare, burial, memorial and other types of assistance to Servicemembers, Veterans, their dependents and survivors.

CrowdMed:  CrowdMed uses ‘the wisdom of crowds’ to help solve even the world’s most difficult medical cases quickly and accurately online. After four years of development and refinement, our patented prediction market technology can suggest diagnoses to real-world medical cases that have stumped doctors for years. Instead of relying on individual physicians, CrowdMed gathers the collective intelligence of hundreds of Medical Detectives (MD’s) to produce astonishingly accurate diagnoses in just hours.

Corengi:  We are re-inventing how patients explore and connect with clinical trials. We educate and engage potential participants and then supply innovative technology to connect them with research that is right for them. Along with empowering these individuals, our platform helps recruit participants for ongoing research studies fundamentally accelerating the pace of medical innovation. 

CarePlanners:  CarePlanners is a service that helps you manage life’s changes – serious illness, new diagnosis, or need for senior services. CarePlanners eliminates the frustrations of healthcare so you can make the best decisions for yourself and your loved ones. Our network of healthcare experts (social workers, nurses, billing and insurance experts) along with our online tools, simplify and clarify health + care. Alan Blaustein founded CarePlanners with Dr. Nancy Synderman, Chief Medical Editor for NBC News.

Brain Sentry: Brain Sentry has developed a helmet-mounted sensor that alerts when an athlete experiences a big impact to his/her head. Playing with an undiagnosed concussion and suffering repeated concussions can have dire consequences for an athlete. One of the biggest challenges in concussion management is determining if a head impact in a game or practice was hard enough to warrant sideline evaluation. Primary targeted customers include youth leagues for football, lacrosse and hockey.

Avado: Avado greatly improves communication between patients, families and their health team … during the 99% of time they’re away from the clinic. Avado is the market-defining Patient Relationship Management system as the first cloud-based EHR-agnostic patient engagement platform built specifically for healthcare providers in accountable models. Avado partners with EHR vendors and mobile app developers to provide their customers a competitive advantage over siloed systems that don’t work well with other systems.

ActualMeds: The ActualMeds Corp. solution supports team-based medication management and medication reconciliation for high-risk patients, improving patient outcomes and reducing hospitalizations, ED visits and readmissions. Cloud-based software automatically accesses medication information available from a patient's EMR, which is reconciled with self-reported behavior. An evidenced-based rules engine identifies risk in the patient's therapeutic regimen for the care team. All data are structured, validated and available for analysis and exchange.

AdhereTech: AdhereTech has created patented smart pill bottles that improve medication adherence. These bottles measure the exact number of pills (or amount of liquid) in the bottle in real-time, wirelessly send this HIPAA-compliant data into the cloud, and remind patients to take their medication via phone call or text message. The devices are built with an open API, which facilitates partnerships and fosters integration with other adherence solutions. In addition to increasing adherence, the bottles record and send granular data that, until now, has only been collected in trials - never before in the real world. 

AchieveMint: The AchieveMint Platform delivers a unique gateway between the healthcare industry and consumers through the mobile app ecosystem. AchieveMint provides an advertising platform as well as analysis of smart data. The aggregated smart data collected from the application provides insight into what motivates life changing healthy behaviors to enable evidence-based decision-making that isn’t available today. The platform not only incentivizes individuals to engage in healthy behavior, it improves outcomes through a combination of social networking and rewards.